An integrative analysis of DNA methylation in osteosarcoma.

ABSTRACT:

Background

The study aimed to analyze aberrantly methylated genes, relevant pathways and transcription factors (TFs) in osteosarcoma (OS) development.

Methods

Based on the DNA methylation microarray data GSE36002 that were downloaded from GEO database, the differentially methylated genes in promoter regions were identified between OS and normal samples. Pathway and function enrichment analyses of differentially methylated genes was performed. Subsequently, protein-protein interaction (PPI) network was constructed, followed by identification of cancer-associated differentially methylated genes and significant differentially methylated TFs.

Results

A total of 1379 hyper-methylation regions and 169 hypo-methylation regions in promoter regions were identified in OS sample

SUBMITTER: Xu J 

PROVIDER: S-EPMC5715438 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature