Performance of the marginal structural cox model for estimating individual and joined effects of treatments given in combination.

ABSTRACT:

Background

The Marginal Structural Cox Model (Cox-MSM), an alternative approach to handle time-dependent confounder, was introduced for survival analysis and applied to estimate the joint causal effect of two time-dependent nonrandomized treatments on survival among HIV-positive subjects. Nevertheless, Cox-MSM performance in the case of multiple treatments has not been fully explored under different degree of time-dependent confounding for treatments or in case of interaction between treatments. We aimed to evaluate and compare the performance of the marginal structural Cox model (Cox-MSM) to the standard Cox model in estimating the treatment effect in the case of multiple treatments under different scenarios of time-dependent confounding and when an interaction between treatment e

SUBMITTER: Lusivika-Nzinga C 

PROVIDER: S-EPMC5715511 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature