Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway.

ABSTRACT:

Background and purpose

An ever-growing wealth of information on current drugs and their pharmacological effects is available from online databases. As our understanding of systems biology increases, we have the opportunity to predict, model and quantify how drug combinations can be introduced that outperform conventional single-drug therapies. Here, we explore the feasibility of such systems pharmacology approaches with an analysis of the mevalonate branch of the cholesterol biosynthesis pathway.

Experimental approach

Using open online resources, we assembled a computational model of the mevalonate pathway and compiled a set of inhibitors directed against targets in this pathway. We used computational optimization to identify combination and dose options that show not only m

SUBMITTER: Benson HE 

PROVIDER: S-EPMC5715582 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature