The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.

ABSTRACT:

Background and purpose

Gabapentin is commonly prescribed for nerve pain but may also cause dizziness, sedation and gait disturbances. Similarly, inhibition of the endogenous cannabinoid enzyme monoacylglycerol lipase (MAGL) has antinociceptive and anti-inflammatory properties but also induces sedation in mice at high doses. To limit these side effects, the present study investigated the analgesic effects of coadministering a MAGL inhibitor with gabapentin.

Experimental approach

Mice subjected to the chronic constriction injury model of neuropathic pain were administered the MAGL inhibitor KML29 (1-40 mg·kg^-1 , i.p.), gabapentin (1-50 mg·kg^-1 , i.p.) or both compounds. Mice were tested for mechanical and cold allodynia. The function and expression of can

SUBMITTER: Crowe MS 

PROVIDER: S-EPMC5715597 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature