Synthetic peptides designed to modulate adiponectin assembly improve obesity-related metabolic disorders.

ABSTRACT:

Background and purpose

Adiponectin, an adipokine possessing profound insulin-sensitizing and anti-inflammatory properties, is a potent biotherapeutic agent . The trimeric adiponectin subunit assembles into hexameric and functionally important higher molecular weight (HMW) forms, controlled by the endoplasmic reticulum protein 44 (ERp44). Obesity-induced ER stress decreases the HMW form in serum, contributing to the development of insulin resistance and Type 2 diabetes. In this study, a panel of synthetic peptides, designed to target ERp44-adiponectin interactions, were tested for their effects on circulating levels of HMW adiponectin.

Experimental approach

Peptides derived from the ERp44 binding region of adiponectin and immunoglobulin IgM were synthesized with or without a

SUBMITTER: Hampe L 

PROVIDER: S-EPMC5715598 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature