Anti-aggregant tau mutant promotes neurogenesis.

ABSTRACT:

Background

The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss in the hippocampus whereas the anti-aggregant form has no deleterious effects. These two proteins differ mainly in their propensity to form ß structure and hence to aggregate.

Methods

To elucidate the basis of these contrasting effects, we analyzed organotypic hippocampal slice cultures (OHSCs) from transgenic mice expressing the repeat domain (RD) of Tau with the anti-aggregant mutation (Tau^RDΔKPP) and compared them with slices containing pro-aggregant Tau^RDΔK. Transgene expression in the hippocampus wa

SUBMITTER: Joseph M 

PROVIDER: S-EPMC5715613 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature