Assigning chemoreceptors to chemosensory pathways in Pseudomonas aeruginosa.

ABSTRACT: In contrast to Escherichia coli, a model organism for chemotaxis that has 5 chemoreceptors and a single chemosensory pathway, Pseudomonas aeruginosa PAO1 has a much more complex chemosensory network, which consists of 26 chemoreceptors feeding into four chemosensory pathways. While several chemoreceptors were rigorously linked to specific pathways in a series of experimental studies, for most of them this information is not available. Thus, we addressed the problem computationally. Protein-protein interaction network prediction, coexpression data mining, and phylogenetic profiling all produced incomplete and uncertain assignments of chemoreceptors to pathways. However, comparative sequence analysis specifically targeting chemoreceptor regions involved in pathway interactions

SUBMITTER: Ortega DR 

PROVIDER: S-EPMC5715753 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature