Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction.

ABSTRACT: Helminths trigger multiple immunomodulatory pathways that can protect from sepsis. Human resistin (hRetn) is an immune cell-derived protein that is highly elevated in helminth infection and sepsis. However, the function of hRetn in sepsis, or whether hRetn influences helminth protection against sepsis, is unknown. Employing hRetn-expressing transgenic mice (hRETNTg⁺) and recombinant hRetn, we identify a therapeutic function for hRetn in lipopolysaccharide (LPS)-induced septic shock. hRetn promoted helminth-induced immunomodulation, with increased survival of Nippostrongylus brasiliensis (Nb)-infected hRETNTg⁺ mice after a fatal LPS dose compared with naive mice or Nb-infected hRETNTg^- mice. Employing immunoprecipita

SUBMITTER: Jang JC 

PROVIDER: S-EPMC5715788 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature