ERDO - a framework to select an appropriate randomization procedure for clinical trials.

ABSTRACT:

Background

Randomization is considered to be a key feature to protect against bias in randomized clinical trials. Randomization induces comparability with respect to known and unknown covariates, mitigates selection bias, and provides a basis for inference. Although various randomization procedures have been proposed, no single procedure performs uniformly best. In the design phase of a clinical trial, the scientist has to decide which randomization procedure to use, taking into account the practical setting of the trial with respect to the potential of bias. Less emphasis has been placed on this important design decision than on analysis, and less support has been available to guide the scientist in making this decision.

Methods

We propose a framework that weights the prope

SUBMITTER: Hilgers RD 

PROVIDER: S-EPMC5715815 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature