Selective targeting of M-type potassium K_v 7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression-like behaviour.

ABSTRACT:

Background and purpose

The mesolimbic dopamine system originating in the ventral tegmental area (VTA) is involved in the development of depression, and firing patterns of VTA dopaminergic neurons are key determinants in this process. Here, we describe a crucial role for the M-type K_v 7.4 channels in modulating excitability of VTA dopaminergic neurons and in the development of depressive behaviour in mice.

Experimental approach

We used K_v 7.4 channel knockout mice and a social defeat model of depression in combination with electrophysiological techniques (patch clamp recording and in vivo single-unit recordings), immunohistochemistry, single-cell PCR and behavioural analyses (social interaction time and glucose preference tests) to investigate VTA circui

SUBMITTER: Li L 

PROVIDER: S-EPMC5715975 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature