Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia.

ABSTRACT:

Background

Aspergillus fumigatus is a human fungal pathogen that causes aspergillosis in immunocompromised hosts. A. fumigatus is believed to be exposed to diverse environmental stresses in the host cells. The adaptation mechanisms are critical for infections in human bodies. Transcriptional networks in response to diverse environmental challenges remain to be elucidated. To gain insights into the adaptation to environmental stresses in A. fumigatus mycelia, we conducted time series transcriptome analyses.

Results

With the aid of RNA-seq, we explored the global gene expression profiles of mycelia in A. fumigatus upon exposure to diverse environmental changes, including heat, superoxide, and osmotic stresses. From the perspective of global transcriptomes, transient responses

SUBMITTER: Takahashi H 

PROVIDER: S-EPMC5715996 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature