Biomarkers of collagen turnover are related to annual change in FEV₁ in patients with chronic obstructive pulmonary disease within the ECLIPSE study.

ABSTRACT:

Background

Change in forced expiratory volume in one second (FEV₁) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of change in FEV₁.

Methods

One thousand COPD subjects from the observational, multicentre, three-year ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) study (NCT00292552, trial registration in February 2006) were included. Matrix metalloproteinase (MMP)-generated fragments of collagen type I, and type VI (C1M and C6M) were assessed in month six serum samples. A random-coefficient model with both a random intercept and a random slope was used to test the ability of the markers to predict post-dose bro

SUBMITTER: Leeming DJ 

PROVIDER: S-EPMC5716018 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature