Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females.

ABSTRACT:

Background

Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotonergic system and the risk that neuroticism poses to the individual, sex may modify the association between neuroticism and serotonin transporter, but this question has not been investigated by previous studies.

Methods

Here, we combined data from 4 different positron emission tomography imaging centers to address whether neuroticism is related to serotonin transporter binding in vivo. Th

SUBMITTER: Tuominen L 

PROVIDER: S-EPMC5716061 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature