Achieving high convection volumes in postdilution online hemodiafiltration: a prospective multicenter study.

ABSTRACT: Background. Available evidence suggests a reduced mortality risk for patients treated with high-volume postdilution hemodiafiltration (HDF) when compared with hemodialysis (HD) patients. As the magnitude of the convection volume depends on treatment-related factors rather than patient-related characteristics, we prospectively investigated whether a high convection volume (defined as ≥22 L/session) is feasible in the majority of patients (>75%). Methods. A multicenter study was performed in adult prevalent dialysis patients. Nonparticipating eligible patients formed the control group. Using a stepwise protocol, treatment time (up to 4 hours), blood flow rate (up to 400 mL/min) and filtration fraction (up to 33%) were optimized as much as possible. The convection volume was det

SUBMITTER: de Roij van Zuijdewijn CLM 

PROVIDER: S-EPMC5716186 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature