The p75^NTR-mediated effect of nerve growth factor in L6C5 myogenic cells.

ABSTRACT:

Objective

During muscle development or regeneration, myocytes produce nerve growth factor (NGF) as well as its tyrosine-kinase and p75-neurotrophin (p75^NTR) receptors. It has been published that the p75^NTR receptor could represent a key regulator of NGF-mediated myoprotective effect on satellite cells, but the precise function of NGF/p75 signaling pathway on myogenic cell proliferation, survival and differentiation remains fragmented and controversial. Here, we verified the role of NGF in the growth, survival and differentiation of p75^NTR-expressing L6C5 myogenic cells, specifically inquiring for the putative involvement of the nuclear factor κB (NFκB) and the small heat shock proteins (sHSPs) αB-crystallin and Hsp27 in these processes.

Results</

SUBMITTER: de Perini A 

PROVIDER: S-EPMC5716223 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature