Dual role for DOCK7 in tangential migration of interneuron precursors in the postnatal forebrain.

ABSTRACT: Throughout life, stem cells in the ventricular-subventricular zone generate neuroblasts that migrate via the rostral migratory stream (RMS) to the olfactory bulb, where they differentiate into local interneurons. Although progress has been made toward identifying extracellular factors that guide the migration of these cells, little is known about the intracellular mechanisms that govern the dynamic reshaping of the neuroblasts' morphology required for their migration along the RMS. In this study, we identify DOCK7, a member of the DOCK180-family, as a molecule essential for tangential neuroblast migration in the postnatal mouse forebrain. DOCK7 regulates the migration of these cells by controlling both leading process (LP) extension and somal translocation via distinct pathways. It control

SUBMITTER: Nakamuta S 

PROVIDER: S-EPMC5716287 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature