Maternal diabetes and incidence of childhood cancer - a nationwide cohort study and exploratory genetic analysis.

ABSTRACT:

Background

The etiology of childhood cancer is not well understood, but may be linked to prenatal and perinatal factors, such as maternal diabetes. However, this association has not been examined in depth. We aimed to determine if maternal diabetes is associated with risk of childhood brain tumor (CBT), leukemia (all types combined and acute lymphoblastic leukemia [ALL] separately), and lymphoma.

Methods

All children born in Sweden between 1973 and 2014 (n=4,239,965) were followed from birth until first cancer diagnosis, age 15 years, or December 31, 2015. Data on maternal diabetes, childhood cancer, and covariates were obtained from nationwide health registers. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using Cox regression adjusted for

SUBMITTER: Deleskog A 

PROVIDER: S-EPMC5716336 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature