The ABC model of prostate cancer: A conceptual framework for the design and interpretation of prognostic studies.

ABSTRACT: There has been limited success in identifying prognostic biomarkers in prostate cancer. A partial explanation may be that insufficient emphasis has been put on clearly defining what type of marker or patient category a biomarker study aims to identify and how different cohort characteristics affect the ability to identify such a marker. In this article, the authors put forth the ABC model of prostate cancer, which defines 3 groups of patients with localized disease that an investigator may seek to identify: patients who, within a given time frame, will not develop metastases even if untreated (category A), will not develop metastases because of radical treatment (category B), or will develop metastases despite radical treatment (category C). The authors demonstrate that follow-up time and

SUBMITTER: Pettersson A 

PROVIDER: S-EPMC5716345 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature