Active immunotherapy for TNF-mediated inflammation using self-assembled peptide nanofibers.

ABSTRACT: Active immunotherapies raising antibody responses against autologous targets are receiving increasing interest as alternatives to the administration of manufactured antibodies. The challenge in such an approach is generating protective and adjustable levels of therapeutic antibodies while at the same time avoiding strong T cell responses that could lead to autoimmune reactions. Here we demonstrate the design of an active immunotherapy against TNF-mediated inflammation using short synthetic peptides that assemble into supramolecular peptide nanofibers. Immunization with these materials, without additional adjuvants, was able to break B cell tolerance and raise protective antibody responses against autologous TNF in mice. The strength of the anti-TNF antibody response could be tuned by adjus

SUBMITTER: Mora-Solano C 

PROVIDER: S-EPMC5716349 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature