Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome.

ABSTRACT:

Background

Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a recent meta-analysis of 38 articles found that of 77 different cytokines measured in plasma, transforming growth factor beta (TGF-β) was the only one that was elevated in patients compared to controls in a sufficient number of articles. In the present study we therefore compared the plasma levels of the three TGF-β isoforms in adolescent CFS patients and healthy controls. In addition, the study explored associations between TGF-β levels, neuroendocrine markers, clinical markers and differentially expressed genes within the CFS group.

Methods

CFS patients aged 1

SUBMITTER: Wyller VB 

PROVIDER: S-EPMC5716371 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature