Folate receptor-targeted molecular imaging improves identification of malignancy during pulmonary resection: a case report.

ABSTRACT:

Background

During minimally invasive pulmonary resection, both limited visualization and tactile feedback can make localization of pulmonary nodules and assessment for synchronous disease challenging. Intraoperative molecular imaging is an emerging technology that can enhance a surgeon's ability to detect cancers at the time of resection.

Case presentation

In this report, we describe the application of a folate receptor-targeted, near infrared optical contrast agent (OTL38) for the detection of an invasive pulmonary adenocarcinoma. During molecular imaging, an otherwise undetectable synchronous nodule was also identified. This finding resulted in intraoperative upstaging and operative plan modifications.

Conclusion

This report marks the first successful utilization of

SUBMITTER: Predina JD 

PROVIDER: S-EPMC5716373 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature