Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart.

ABSTRACT:

Aims

The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy. We have previously shown that the Z-disc protein Cytoskeletal Heart-enriched Actin-associated Protein (CHAP) is essential for cardiac and skeletal muscle development. Furthermore, the CHAP gene has been associated with atrial fibrillation in humans. Here, we studied the misregulated expression of CHAP isoforms in heart disease.

Methods and results

Mice that underwent transverse aortic constriction and calcineurin transgenic (Tg) mice, both models of experimental heart failure, displayed a significant increase in cardiac expression of fetal isoform CHAPb. To investigate whether increased expression of CHAP

SUBMITTER: van Eldik W 

PROVIDER: S-EPMC5716575 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature