Influence of socioeconomic status on the whole blood transcriptome in African Americans.

ABSTRACT:

Background

The correlation between low socioeconomic status (SES) and poor health outcome or higher risk of disease has been consistently reported by many epidemiological studies across various race/ancestry groups. However, the biological mechanisms linking low SES to disease and/or disease risk factors are not well understood and remain relatively under-studied. The analysis of the blood transcriptome is a promising window for elucidating how social and environmental factors influence the molecular networks governing health and disease. To further define the mechanistic pathways between social determinants and health, this study examined the impact of SES on the blood transcriptome in a sample of African-Americans.

Methods

An integrative approach leveraging three complemen

SUBMITTER: Gaye A 

PROVIDER: S-EPMC5716587 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature