Prognostic value of ALDH2 polymorphism for patients with oropharyngeal cancer in a Japanese population.

ABSTRACT:

Background

Half of Japanese possess a polymorphism of aldehyde dehydrogenase 2(ALDH2), while few white individuals possess this mutation. The purpose of this study was to investigate the possibility of ALDH2 polymorphism as a prognostic factor for oropharyngeal cancer (OPC) among Japanese population.

Methods

We analyzed 82 Japanese patients with OPC treated between 2006 and 2011. The median observation period was 50 months. P16-staining and ALDH2 polymorphisms were investigated. To examine the frequencies of second primary pharyngeal and esophageal cancers (SPPEC),37 Japanese patients with OPC treated at Tokyo University Hospital were included for statistical analysis.

Results

Statistically significant differences were noted in OS among sex, age, N classification, and

SUBMITTER: Shinomiya H 

PROVIDER: S-EPMC5716598 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature