Zingerone alleviates the delayed ventricular repolarization and AV conduction in diabetes: Effect on cardiac fibrosis and inflammation.

ABSTRACT:

Background

The study aims to analyse the action of zingerone in diabetes-related cardiac arrhythmias.

Methods

Diabetes was induced by streptozocin while treatment groups received 20 mg/kg zingerone daily. Following extra seven weeks, electrocardiography, extraction of blood, urine and heart for biochemical analysis, histopathology and immunofluorescence were undertaken.

Results

The suppression of QT and QTc prolongation in diabetic rats was indicative of prolonged cardiac repolarisation that was greatly reduced by zingerone treatment. In addition, the reduction in PR interval attested that zingerone improved AV delay in diabetic rats. The fibrogenic transforming growth factor β1 upregulation in diabetic hearts was suppressed by zingerone. The marked glycogen depositio

SUBMITTER: El-Bassossy HM 

PROVIDER: S-EPMC5716606 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature