An Aedes aegypti-associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity.

ABSTRACT: Transmission of dengue virus (DENV) requires successful completion of the infection cycle in the Aedes aegypti vector, which is initiated in the midgut tissue after ingestion of an infectious blood meal. While certain Ae. aegypti midgut-associated bacteria influence virus infection, little is known about the midgut-associated fungi (mycobiota), and how its members might influence susceptibility to DENV infection. We show that a Talaromyces (Tsp_PR) fungus, isolated from field-caught Ae. aegypti, render the mosquito more permissive to DENV infection. This modulation is attributed to a profound down-regulation of digestive enzyme genes and trypsin activity, upon exposure to Tsp_PR-secreted factors. In conclusion, we show for the first time that a nat

SUBMITTER: Anglero-Rodriguez YI 

PROVIDER: S-EPMC5716662 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature