Protein tyrosine phosphatase receptor-type δ acts as a negative regulator suppressing breast cancer.

ABSTRACT: Protein tyrosine phosphatase receptor-type δ (PTPRD) is frequently inactivated in human cancers. This study investigated the role of PTPRD in the regulation of stemness, epithelial-mesenchymal transition (EMT), and migration and invasion in breast cancer cells. In vitro, PTPRD silencing using siRNA enhanced the stem cell-like properties of breast cancer cells, including their mammosphere- and holoclone-forming abilities, and it promoted tumorigenicity in vivo. PTPRD knockdown also increased the CD44⁺/CD24^- breast cancer stem cell (BCSC) population and the expression of the stem cell markers ALDH1 and OCT4. It also promoted migration and invasion by breast cancer cell, EMT, and activation of signal transducer and activator of transcription 3 (STAT3). BCSC

SUBMITTER: Yu X 

PROVIDER: S-EPMC5716768 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature