Development and validation of a model for staging hepatic fibrosis for chronic hepatitis B patients with E antigen-positive.

ABSTRACT:

Background

Interest is growing in the use of non-invasive techniques for complementing liver biopsy for liver fibrosis assessment. We aimed to prospectively evaluate liver histology in chronic hepatitis B (CHB) patients with e-antigen positivity, and develop and validate a novel scoring system-e-antigen-positive CHB liver fibrosis (EPLF) score-for noninvasively predicting the fibrosis stages.

Methods

We identified the baseline variables associated with fibrosis stage (MATAVIR score, F0-F4) in 212 CHB patients with e-antigen positivity. These significant variables were used to develop the EPLF scoring system. The EPLF score equation was developed based on the prediction of fibrosis stages via multivariate ordered logistic regression analysis. The diagnostic powers of the EPLF

SUBMITTER: Wang H 

PROVIDER: S-EPMC5716769 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature