Reduced m⁶A mRNA methylation is correlated with the progression of human cervical cancer.

ABSTRACT: The m⁶A mRNA methylation involves in mRNA splicing, degradation and translation. Recent studies have revealed that reduced m⁶A mRNA methylation might promote cancer development. However, the role of m⁶A mRNA methylation in cervical cancer development remains unknown. Therefore, we investigated the role of m⁶A methylation in cervical cancer in the current study. We first evaluated the m⁶A mRNA methylation level in 286 pairs of cervical cancer samples and their adjacent normal tissues by dot blot assay. Then the role of m⁶A on patient survival rates and cervical cancer progression were assessed. The m⁶A level was significantly reduced in the cervical cancer when comparing with the adjacent normal tissue. The m⁶

SUBMITTER: Wang X 

PROVIDER: S-EPMC5716777 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature