Altered circadian feeding behavior and improvement of metabolic syndrome in obese Tac1-deficient mice.

ABSTRACT:

Background

Metabolic function is regulated by the interplay of central and peripheral factors that ultimately regulate food intake (FI) and energy expenditure. The tachykinin substance P (SP) has been identified as a novel regulator of energy balance, however, the mechanisms underlying this effect are ill-defined and conflicting data regarding the role of SP on FI have been reported by different groups.

Objective

To further characterize the metabolic role of the Tac1 gene products (SP and neurokinin A) in mice through a series of genetic, metabolic and behavioral studies in Tac1-deficient mice.

Results

Tac1^-/- mice are leaner than controls and display reduced FI and altered feeding circadian rhythm, supported by disrupted expression of the clock genes Cry1/

SUBMITTER: Maguire CA 

PROVIDER: S-EPMC5716839 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature