Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity.

ABSTRACT:

Importance

Evidence is lacking regarding the consequences of antibiotic use in early life and the risk of certain autoimmune diseases.

Objective

To test the association between early-life antibiotic use and islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up for type 1 diabetes (T1D) or CD.

Design, setting, and participants

HLA-genotyped newborns from Finland, Germany, Sweden, and the United States were enrolled in the prospective birth cohort of The Environmental Determinants of Diabetes in the Young (TEDDY) study between November 20, 2004, and July 8, 2010. The dates of analysis were November 20, 2004, to August 31, 2014. Individuals from the general population and those having a first-degree relative with T1D were enr

SUBMITTER: Kemppainen KM 

PROVIDER: S-EPMC5716863 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature