Tryptophan-Derived 3-Hydroxyanthranilic Acid Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice In Vivo.

ABSTRACT:

Background

Abnormal amino acid metabolism is associated with vascular disease. However, the causative link between dysregulated tryptophan metabolism and abdominal aortic aneurysm (AAA) is unknown.

Methods

Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism. Mice with deficiencies in both apolipoprotein e (Apoe) and IDO (Apoe^-/-/IDO^-/-) were generated by cross-breeding IDO^-/- mice with Apoe^-/- mice.

Results

The acute infusion of angiotensin II markedly increased the incidence of AAA in Apoe^-/- mice, but not in Apoe^-/-/IDO^-/- mice, which presented decreased elastic lamina degradation and aortic expansion. These features wer

SUBMITTER: Wang Q 

PROVIDER: S-EPMC5716872 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature