The GNAS^R201C mutation associated with clonal hematopoiesis supports transplantable hematopoietic stem cell activity.

ABSTRACT: Genome sequencing efforts have identified virtually all of the important mutations in adult myeloid malignancies. More recently, population studies have identified cancer-associated variants in the blood of otherwise healthy individuals as they age, a phenomenon termed clonal hematopoiesis of indeterminate potential (CHIP). This suggests that these mutations may occur in hematopoietic stem cells (HSCs) long before any clinical presentation but are not necessarily harbingers of transformation because only a fraction of individuals with CHIP develop hematopoietic pathologies. Delineation between CHIP variants that predispose for disease versus those that are more benign could be used as a prognostic factor to identify individuals at greater risk for transformation. To achieve this, the biolo

SUBMITTER: Ostrander EL 

PROVIDER: S-EPMC5716908 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature