Parkinson's disease susceptibility variants and severity of Lewy body pathology.

ABSTRACT:

Introduction

Meta-analyses of genome-wide association studies (GWAS) have established common genetic risk factors for clinical Parkinson's disease (PD); however, associations between these risk factors and quantitative neuropathologic markers of disease severity have not been well-studied. This study evaluated associations of nominated variants from the most recent PD GWAS meta-analysis with Lewy body disease (LBD) subtype (brainstem, transitional, or diffuse) and pathologic burden of LB pathology as measured by LB counts in five cortical regions in a series of LBD cases.

Methods

547 autopsy-confirmed cases of LBD were included and genotyped for 29 different GWAS-nominated PD risk variants. LB counts were measured in middle frontal (MF), superior temporal (ST), inferior pari

SUBMITTER: Heckman MG 

PROVIDER: S-EPMC5716921 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature