Fabrication of dense anisotropic collagen scaffolds using biaxial compression.

ABSTRACT: We developed a new method to manufacture dense, aligned, and porous collagen scaffolds using biaxial plastic compression of type I collagen gels. Using a novel compression apparatus that constricts like an iris diaphragm, low density collagen gels were compressed to yield a permanently densified, highly aligned collagen material. Micro-porosity scaffolds were created using hydrophilic elastomer porogens that can be selectively removed following biaxial compression, with porosity modulated by using different porogen concentrations. The resulting scaffolds exhibit collagen densities that are similar to native connective tissues (∼10% collagen by weight), pronounced collagen alignment across multiple length scales, and an interconnected network of pores, making them highly relevant for use in

SUBMITTER: Zitnay JL 

PROVIDER: S-EPMC5716932 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature