Improved threshold selection for the determination of volume of distribution of nanoparticles administered by convection-enhanced delivery.

ABSTRACT: Nanotechnology, in conjunction with convection-enhanced delivery (CED), has gained traction as a promising method to treat many debilitating neurological diseases, including gliomas. One of the key parameters to evaluate the effectiveness of delivery is the volume of distribution (V_d) of nanoparticles within the brain parenchyma. Measurements of V_d are commonly made using fluorescent reporter systems. However, reported analyses lack accurate and robust methods for determining V_d. Current methods face the problems of varying background intensities between images, high intensity aggregates that can shift intensity distributions, and faint residual backgrounds that can occur as artifacts of fluorescent imaging. These problems can cause inaccurate results to be

SUBMITTER: Chi DL 

PROVIDER: S-EPMC5716935 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature