Progress toward Development of a Vaccine against Congenital Cytomegalovirus Infection.

ABSTRACT: A vaccine against congenital human cytomegalovirus (CMV) infection is a major public health priority. Congenital CMV causes substantial long-term morbidity, particularly sensorineural hearing loss (SNHL), in newborns, and the public health impact of this infection on maternal and child health is underrecognized. Although progress toward development of a vaccine has been limited by an incomplete understanding of the correlates of protective immunity for the fetus, knowledge about some of the key components of the maternal immune response necessary for preventing transplacental transmission is accumulating. Moreover, although there have been concerns raised about observations indicating that maternal seropositivity does not fully prevent recurrent maternal CMV infections during pregnancy, it

SUBMITTER: Schleiss MR 

PROVIDER: S-EPMC5717185 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature