New Hybrid Hydrazinyl Thiazole Substituted Chromones: As Potential α-Amylase Inhibitors and Radical (DPPH & ABTS) Scavengers.

ABSTRACT: Current research is based on the identification of novel inhibitors of α-amylase enzyme. For that purpose, new hybrid molecules of hydrazinyl thiazole substituted chromones 5-27 were synthesized by multi-step reaction and fully characterized by various spectroscopic techniques such as EI-MS, HREI-MS, ¹H-NMR and ¹³C-NMR. Stereochemistry of the iminic bond was confirmed by NOESY analysis of a representative molecule. All compounds 5-27 along with their intervening intermediates 1-4, were screened for in vitro α-amylase inhibitory, DPPH and ABTS radical scavenging activities. All compounds showed good inhibition potential in the range of IC₅₀ = 2.186-3.405 µM as compared to standard acarbose having IC₅₀ value of 1.9 ± 0.07 µM. It is worth mentioning

SUBMITTER: Salar U 

PROVIDER: S-EPMC5717224 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature