Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response.

ABSTRACT: Cancer is a complex disease involving multiple genomic alterations that disrupt the dynamic response of signaling networks. The heterogeneous nature of cancer, which results in highly variable drug response, is a major obstacle to developing effective cancer therapy. Previous studies of cancer therapeutic response mostly focus on static analysis of genome-wide alterations, thus they are unable to unravel the dynamic, network-specific origin of variation. Here we present a network dynamics-based approach to integrate cancer genomics with dynamics of biological network for drug response prediction and design of drug combination. We select the p53 network as an example and analyze its cancer-specific state transition dynamics under distinct anticancer drug treatments by attractor landscape an

SUBMITTER: Choi M 

PROVIDER: S-EPMC5717260 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature