Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions.

ABSTRACT: Colorectal cancer (CRC) has complex pathological features that defy the linear-additive reasoning prevailing in current biomedicine studies. In pursuing a mechanistic understanding behind such complexity, we constructed a core molecular-cellular interaction network underlying CRC and investigated its nonlinear dynamical properties. The hypothesis and modelling method has been developed previously and tested in various cancer studies. The network dynamics reveal a landscape of several attractive basins corresponding to both normal intestinal phenotype and robust tumour subtypes, identified by their different molecular signatures. Comparison between the modelling results and gene expression profiles from patients collected at the second affiliated hospital of Zhejiang University is presented

SUBMITTER: Yuan R 

PROVIDER: S-EPMC5717345 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature