Proposed Role for KaiC-Like ATPases as Major Signal Transduction Hubs in Archaea.

ABSTRACT: All organisms must adapt to ever-changing environmental conditions and accordingly have evolved diverse signal transduction systems. In bacteria, the most abundant networks are built around the two-component signal transduction systems that include histidine kinases and receiver domains. In contrast, eukaryotic signal transduction is dominated by serine/threonine/tyrosine protein kinases. Both of these systems are also found in archaea, but they are not as common and diversified as their bacterial and eukaryotic counterparts, suggesting the possibility that archaea have evolved other, still uncharacterized signal transduction networks. Here we propose a role for KaiC family ATPases, known to be key components of the circadian clock in cyanobacteria, in archaeal signal transduction. The Kai

SUBMITTER: Makarova KS 

PROVIDER: S-EPMC5717392 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature