Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development.

ABSTRACT: Planar cell polarity (PCP) is an evolutionarily conserved essential mechanism that provides directional information to control and coordinate polarized cellular and tissue behavior during embryonic development. Disruption of PCP leads to severe morphological defects in vertebrates and its dysregulation results in a variety of human diseases such as neural tube defects and skeletal dysplasia. PCP is governed by a set of highly conserved core proteins that are asymmetrically localized at the cell surface throughout the polarized tissues. The uniform directionality of PCP is established by global cues, such as Wg/Wnt signaling gradients that break the original symmetrical localization of core PCP proteins including Vang/Vangl and Fz/Fzd. However, the exact mechanism remains elusive. In this s

SUBMITTER: Yang W 

PROVIDER: S-EPMC5717403 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature