The role of necrosis, acute hypoxia and chronic hypoxia in ¹⁸F-FMISO PET image contrast: a computational modelling study.

ABSTRACT: Positron emission tomography (PET) using ¹⁸F-fluoromisonidazole (FMISO) is a promising technique for imaging tumour hypoxia, and a potential target for radiotherapy dose-painting. However, the relationship between FMISO uptake and oxygen partial pressure ([Formula: see text]) is yet to be quantified fully. Tissue oxygenation varies over distances much smaller than clinical PET resolution (<100 μm versus  ∼4 mm), and cyclic variations in tumour perfusion have been observed on timescales shorter than typical FMISO PET studies (∼20 min versus a few hours). Furthermore, tracer uptake may be decreased in voxels containing some degree of necrosis. This work develops a computational model of FMISO uptake in millimetre-scale tumour regions. Coupled partial differential equations govern

SUBMITTER: Warren DR 

PROVIDER: S-EPMC5717515 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature