Blood-Based Protein Signatures for Early Detection of Colorectal Cancer: A Systematic Review.

ABSTRACT:

Objectives

Blood-based proteins might be an attractive option for early detection of colorectal cancer (CRC), but individually they are unlikely to achieve the diagnostic performance required for population based screening. We aimed at summarizing current evidence of diagnostic performance of signatures based on multiple proteins for early detection of CRC.

Methods

A systematic literature review adhering to the PRISMA (preferred reporting items for systematic reviews and meta-analysis) guidelines was performed. PubMed and Web of Science databases were searched for potentially relevant studies published until 28th August, 2017. Relevant studies were identified by predefined eligibility criteria. Estimates of indicators of diagnostic performance such as sensitivity, specificit

SUBMITTER: Bhardwaj M 

PROVIDER: S-EPMC5717517 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature