Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis.

ABSTRACT:

Objective

To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's disease.

Design

Mendelian randomisation study using genetic variants associated with the modifiable risk factors as instrumental variables.

Setting

International Genomics of Alzheimer's Project.

Participants

17 008 cases of Alzheimer's disease and 37 154 controls.

Main outcome measures

Odds ratio of Alzheimer's per genetically predicted increase in each modifiable risk factor estimated with Mendelian randomisation analysis.

Results

This study included analyses of 24 potentially modifiable risk factors. A Bonferroni corrected threshold of P=0.002 was considered to be

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC5717765 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature