Transcription coupled repair and biased insertion of human retrotransposon L1 in transcribed genes.

ABSTRACT:

Background

L1 retrotransposons inserted within genes in the human genome show a strong bias against sense orientation with respect to the gene. One suggested explanation for this observation was the possibility that L1 inserted randomly, but that there was negative selection against sense-oriented insertions. However, multiple studies have now found that de novo and polymorphic L1 insertions, which have little opportunity for selection to act, also show the same bias.

Results

Here we show that the transcription-coupled sub-pathway of nucleotide excision repair does not affect the overall rate of insertion of L1 elements, which is in contrast with the regulation by the global sub-pathway of nucleotide excision repair. The transcription-coupled subpathway does cause a s

SUBMITTER: Servant G 

PROVIDER: S-EPMC5717806 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature