Identification and validation of a 44-gene expression signature for the classification of renal cell carcinomas.

ABSTRACT:

Background

Renal cancers account for more than 3% of all adult malignancies and cause more than 23,400 deaths per year in China alone. The four most common types of kidney tumours include clear cell, papillary, chromophobe and benign oncocytoma. These histological subtypes vary in their clinical course and prognosis, and different clinical strategies have been developed for their management. Some kidney tumours can be very difficult to distinguish based on the pathological assessment of morphology and immunohistochemistry.

Methods

Six renal cell carcinoma microarray data sets, including 106 clear cell, 66 papillary, 42 chromophobe, 46 oncocytoma and 35 adjacent normal tissue samples, were subjected to integrative analysis. These data were combined and used as a training set

SUBMITTER: Wang Q 

PROVIDER: S-EPMC5717815 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature