Decreased expression of the β₂ integrin on tumor cells is associated with a reduction in liver metastasis of colorectal cancer in mice.

ABSTRACT:

Background

Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its functional role in the metastatic progression to the liver remains unknown. Using in vitro assays and an experimental orthotopic in vivo model of liver metastasis, we aimed to elucidate the role of tumor LFA-1 in the metastatic progression by means of the partial depletion of the β₂ subunit of LFA-1, required for integrin activation, firm adhesion and signaling.

Methods

To do so, we evaluated the effects of β₂ reduction on the murine colon c

SUBMITTER: Benedicto A 

PROVIDER: S-EPMC5718006 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature