Ranges of phenotypic flexibility in healthy subjects.

ABSTRACT:

Background

A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of metabolic health. Furthermore, it was demonstrated that quantification of PFT response was more sensitive as compared to fasting markers in demonstrating reduced phenotypic flexibility in metabolically impaired type 2 diabetes subjects.

Methods

This study aims to demonstrate that quantification of PFT response can discriminate between different states of health within the healthy range of the population. Therefore, 100 healthy subjects

SUBMITTER: van den Broek TJ 

PROVIDER: S-EPMC5718019 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature