Caloric Restriction-Induced Decreases in Dopamine Receptor Availability are Associated with Leptin Concentration.

ABSTRACT:

Objective

It has been previously reported that early after Roux-en-Y-gastric bypass, dopamine (DA) type 2 and 3 receptor (D2/3R) binding potential (BP_ND ) was decreased from preoperative levels. The current study aimed to determine whether calorie restriction without weight loss modifies D2/3R BP_ND and whether such changes are explained by neuroendocrine regulation.

Methods

Fifteen females with obesity (BMI = 39 ± 6 kg/m² ) were studied before and after ∼10 days of a very-low-calorie-diet (VLCD). Outcome measures included fasting insulin, leptin, acyl ghrelin, and glucose, and insulin sensitivity and disposition index were estimated using the oral-minimal model (OMM) method. Participants underwent positron emission tomography scanning with th

SUBMITTER: Dunn JP 

PROVIDER: S-EPMC5718041 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature